Shibchar and Zanjira upazilas on the north, Kalkini and Kotalipara upazilas on the south, Shariatpur Sadar upazila on the east, Rajoir upazila on the west.

Madaripur thana was established in 1964 and was turned into an upazila in 1982. It consists of one municipality, 18 union parishads, 189 mouzas and 185 villages.

Madaripur Sadar Upazila is located in Madaripur District. Upazilla(s)/Thana(s) in Madaripur are Kalkini Upazila, Madaripur Sadar Upazila, Rajoir Upazila, Shibchar Upazila.