Madaripur Sadar and Shariatpur Sadar upazilas on the north, Gournadi and Muladi upazilas on the south, Gosairhat, Muladi and Damudya upazilas on the east, Kotalipara and Gournadi upazilas on the west.

Kalkini thana was established in 1909 and was turned into an upazila in 1984. It consists of 15 union parishads, 160 mouzas and 190 villages.

Kalkini Upazila is located in Madaripur District. Upazilla(s)/Thana(s) in Madaripur are Kalkini Upazila, Madaripur Sadar Upazila, Rajoir Upazila, Shibchar Upazila.

Remnants of the hermitage of the famous saint Syed Usman.